PYRAZOLOPYRIMIDINYL- AND PYRIMIDINYLALKYLIDENE-BIS-PHOSPHONIC ACIDS, THEIR ESTERS OR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: pyrazolopyrimidinyl- and pyrimidinylalkylidene-bis-phosphonic acids, their esters or pharmaceutically acceptable salts of the formulas (I) and (II) where: R1 - H, Na, K, C1-C6-alkyl; R2 - H, C1-C6-alkyl, benzyloxy, C1-C6-alkoxy, phenyl; R6 - H; X - oxygen; R10 - H; R11 - C1-C6-alkyl, benzyl, allyl, phenyl, benzyloxyalkoxy, alkoxyphenyl; R12 - H, halogen; R13 - H, phenyl, pyridinophenyl, or R12 and R13 form together halogen-substituted benzene ring. Reagent 1: pyrazolopyrimidine or pyrimidine. Reagent 2: vinylidenediphosphonate. Reaction conditions: in the presence of strong base in medium of organic solvent. Synthesized compounds were used in medicine as antiinflammatory agents. EFFECT: improved method of synthesis. 12 cl, 2 tbl