FIELD: chemistry of heterocyclic compounds. SUBSTANCE: products: tropone-substituted phenyloxazolidinones of the general formula (I) where R1 is (C1-C8)--alkyl; R2 and R3 are similar or different and taken from hydrogen, fluorine or chlorine; R4 is taken from group consisting of (a) , (b) or (c) ; R5 is taken from group consisting of hydrogenm -OR6, -SR6, -NHR7, -NR7R12,, (d) , (e) , (f) , (g) , (h) or (i) ; R6 is H, (C1-C8)--alkyl possibly substituted with (C1-C8)--alkoxyles, (C2-C8)--alkenyl-(C1-C8)--alkyl or phenyl--(C1-C8)--alkyl; R7 means -(C1-C8)--alkyl optionally substituted with hydroxy-group, phenyl or (C1-C8)--alkoxycarbonyl, (C3-C8)--cycloalkyl, (C2-C8)--alkynyl-(C1-C10)--alkyl, (C2-C8)-alkenyl-(C1-C10)--alkyl; R8 is hydrogen, (C1-C8)-alkyl, (C1-C8)-acyl; R9 and R10 can be similar or different and mean H or (C1-C8)--alkyl; R11 - H, hydroxy- or amino-group; R12 is (C1-C8)-alkyl, or pharmaceutically acceptable salts or hydrates. Synthesized compounds of the formula (I) show antibacterial activity. EFFECT: improved method of synthesis. 19 cl, 3 tbl, 38 ex
Authors
Dates
1998-09-27—Published
1993-10-14—Filed