HYPOTENSIVE AGENT Russian patent published in 1997 - IPC

Abstract RU 2084225 C1

FIELD: organic chemistry. SUBSTANCE: invention proposes the following composition of the medicinal agent: inhibitor of ACE (acetylcholine esterase) - 9(S)-[1(S)-ethoxycarbonyl-3-phenylpropylamino] -octahydro-10- -oxo-6H-pyridazo-[1,2-a] -[1,2] -diazepine-1(S)-carboxylic acid ("Silazapril") as free base, hydrate or pharmaceutically acceptable salt and calcium antagonist - [1S,2S]-2-[2-[[3-(2- -benzimidazolyl)propyl]-methylamino]-ethyl-6-fluoro-1,2,3,4- -tetrahydro-1-isopropyl-2-naphthylmethoxy acetate. Mass ratio of inhibitor of ACE : calcium antagonist = 1:(1-100) as measured for free bases. Preferable ratio = 1:(2-20). Proposed agent is used in medicine for hypertension treatment. EFFECT: enhanced effectiveness of treatment. 2 cl, 3 dwg

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RU 2 084 225 C1

Authors

Zho-Pol' Klozel'[Fr]

Rita Mjuller[Ch]

Vol'Fgang Osterrider[De]

Dates

1997-07-20—Published

1992-07-20—Filed