FIELD: chemistry.
SUBSTANCE: invention relates to compounds of general formula (I) 
, where R is methyl and R1 is 4-methyl-oxy-piperazin-1-yl; or R is CH2OH and R1 is 4-methyl-piperzin-1-yl or 4-methyl-4-oxy-piperazin-1-yl; and to pharmaceutically acceptable acid addition salts thereof, as well as to a medicinal agent based on said compounds, having NK-1 receptor antagonist activity and to use of said compounds in treating NK-1 receptor associated diseases.
EFFECT: compounds can be used in medicine.
9 cl, 2 ex, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 4-PHENYLPYRIDINE AND MEDICINAL AGENT | 2001 |
|
RU2276139C2 |
| APPLICATION OF RECEPTOR NK-1 ANTAGONISTS FOR TREATING CRANIOCEREBRAL AND SPINAL TRAUMAS OR NERVOUS TISSUE LESION | 2002 |
|
RU2304435C2 |
| DERIVATIVES OF 3-PHENYLPYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2236402C2 |
| DERIVATIVES OF BENZENE OR PYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2238264C2 |
| DERIVATIVES OF 4-PHENYLPYRIDINE N-OXIDES, MEDICINAL AGENT COMPRISING THEREOF | 2001 |
|
RU2266284C2 |
| DERIVATIVES OF PYRIMIDINE AND PHARMACEUTICAL COMPOSITION | 2001 |
|
RU2284997C2 |
| DOUBLE NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA | 2005 |
|
RU2374229C2 |
| DERIVATIVES OF 5-PHENYLPYRIMIDINE AND PHARMACEUTICAL COMPOSITION | 2000 |
|
RU2244710C2 |
| DERIVATIVES OF DIPHENYL AND MEDICINAL AGENT | 2000 |
|
RU2238266C2 |
| DERIVATIVES OF 4-PHENYLPYRIMIDINE AND PHARMACEUTICAL COMPOSITION | 2000 |
|
RU2243221C2 |
