PHARMACEUTICAL PREPARATION Russian patent published in 2000 - IPC

FIELD: pharmacy. SUBSTANCE: invention relates to the combined preparation that can be used for treatment of patients with circulation system diseases. Preparation has an inhibitor of renin-angiotensin - cilazapril and an antagonist of endothelin - 4-tert.-butyl-N-[6-(2- -hydroxyethoxy)-5-(2-methoxyphenoxy)-1,2,2'-bipyrimidine-4-yl] - -benzenesulfoneamide at their mass ratio = (1: 1)-(1: 100), respectively. In part, the preparation has 2.5-10 mg of cilazapril and 250-1000 mg of endothelin antagonist. The total mass of both components in the preparation can be 550 mg. Combined administration of two components of the preparation results to the synergistic effect and therefore effective doses of both components can be decreased that diminishes adverse effects. EFFECT: enhanced effectiveness of preparation. 3 cl, 4 dwg, 2 ex