METHOD FOR PREOPERATIVE TREATMENT OF RECTUM CANCER Russian patent published in 1997 - IPC

FIELD: medicine; oncology. SUBSTANCE: prior to operation, endolymphatically, there are administered into patient's lower extremity 5-fluoruracyl in dose 1750- 2000 mg, methotrexate 60-75 mg, cyclophosphamide 1600-2000 mg. After 10-12 days same medicaments are administered into opposite extremity, while simultaneously, subjecting tumor to local treatment with dry mixture of powdery preparations, namely: 5-fluoruracyl 2000-3000 mg, colchamine 10-12 mg, mixture being administered by compressed air jet ejected by air-operated apparatus under pressure 1.5-2 atm. Procedure is repeated after 1-2 days, total number of procedures being 4-6. Once this preoperative treatment course over, patient is subjected to surgical operation. EFFECT: viability and growth of tumor cells suppressed; invasion to surrounding tissues reduced; tumor size reduced; tumor becomes more movable and, thereby, easier to operate; metastases of regional lymphatic nodes suppressed; side effects involved in chemiotherapy ruled out.