FIELD: biotechnology, microbiology. SUBSTANCE: strains of Streptomyces avermitilis that do not show activity of 2-oxo-acid branched chain dehydrogenase and amino acid branched chain transaminase were used for producing natural and unnatural avermectins with the certain value of radical R. Strains Str. avermitilis were deposited in ATCC and have the collection numbers ATCC N 53567, N 53568, N 53669 and N 53670. The produced avermectins show strong antiparasitic activity. EFFECT: improved method of producing. 12 cl, 3 dwg , 4 tbl
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Authors
Dates
1997-11-20—Published
1988-01-22—Filed