METHOD OF SYNTHESIS OF CEPHEM DERIVATIVES, REACTIVE THIOPHOSPHATE DERIVATIVES OF THIA- (OR DIA)ZOLE ACETIC ACID AND A METHOD OF THEIR SYNTHESIS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: products: cephem derivatives of the general formula (I): where: R¹ means carboxy-group or protected carboxy-group that can form salt -COO^-M⁺ with alkaline metal ion ((M⁺)), for example, with sodium ion or can mean -COO^-, when R² has substituent with positive electric charge, for example, pyridinium, pyrimidinium or thiazolium; R² means hydrogen, acylhydroxymethyl, heterocyclic methyl or heterocyclic thiomethyl each of that can be substituted with the corresponding substituents; R³ means hydrogen or amino-protected group; R⁵ means hydrogen, C_1-4-alkyl or -C(R^a)(R^b)CO₂R^c, where R^a and R^b in the group -C(R^a)(R^b)CO₂R^c as R⁵ are similar or distinct each of other and mean H or C₁-C₄-alkyl, or together with carbon atom with which they were bound form C₃-C₇-cycloalkyl group; R^c - hydrogen or carboxy-protecting group; Q - nitrogen atom or CH. EFFECT: improved method of synthesis. 15 cl