FIELD: medicine, pharmacy. SUBSTANCE: solid medicinal formula is made of the cooled granulated melt and has at least one an active component and special additions. Active component is isosorbitol dinitrate or isosorbitol-5-mononitrate. Special additions: structure-forming agent and polymeric thermoplast soluble in the melted active component at temperature from melting point of an active component to decomposition point of its. Polymeric thermoplast is polyvinyl acetate. Method of preparing the solid medicinal formula involves the following stages: mixing an active component and special additions, mixture melting, stirring the melt to the formation of homogeneous mass, granulation and granulate cooling. By the second variant before granulation stage a mixture is extracted in the melt, preferably, at 60-110 C. EFFECT: improved method of preparing, improved quality and property of formula. 10 cl
