DERIVATIVES OF NITRATOALKANOIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: products: derivatives of nitratoalkanoic acids of formula , where R₁ - lower AlkO, bound with peptide bond pentapeptide: Tyr-Pro-Phe-Pro-Gly(OMe); R₁ - H, Alk-Alk(C₁-C₆), acylamino; R₂ - H, lower Alk; R₃ - H; R₄ - H, lower Alk; R₅=(CH₂)_kSX, where X - H, lower Alk or X - COR″, where R″ - H, lower Alk or residue of N-acylaminoacid; m = 0.1-10; n and o = 0-2, or their pharmaceutically acceptable salts. Reagent 1: O₂NOCH₂C(R₁R₂)(CH₂)_mC(O)NR₃(CH₂)_nC(R₄R₆)(CH₂)_oC(O)R ,, where R₆ - alkylthiol. Reagent 2: aminoacid and/or N-acylaminoacid, peptide or N-acylpeptide with 2-5 aminoacid residue bound by peptide bond with thioether formation. Synthesized compounds show low toxicity and used in medicine. EFFECT: improved method of synthesis. 2 tbl