FIELD: organic chemistry. SUBSTANCE: invention relates to new derivative of quinoline (naphthyridine) carboxylic acid of the formula (I) 
that has 4-aminomethyl- -3-oximepyrrolidine substitute at position 7 of quinolone ring and shows high antibacterial activity as compared with the known quinolone antibacterial agents of low activity against gram-positive bacterial strains. Compound of the formula (I) has R, R1, R2, R3, R4 and Q that are similar to indicated in description. The synthesized derivatives show also broad antibacterial spectrum and very improved pharmacokinetic properties. EFFECT: enhanced effectiveness of compounds. 11 cl, 27 tbl, 202 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THROMBIN INHIBITORS OF SELECTIVE ACTION AND PHARMACEUTICAL COMPOSITION BASED ON SAID | 1996 |
|
RU2142939C1 |
| NOVEL METHOD FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE (VARIANTS), INTERMEDIATE COMPOUNDS AND METHOD FOR PREPARING QUINOLONE ANTIBIOTICS | 2004 |
|
RU2303029C2 |
| DEHALOGENATED COMPOUNDS, ANTIBACTERIAL AGENT AND THERAPEUTIC AGENT BASED ON THEREOF, METHOD FOR PREPARING ANTIBACTERIAL OR MEDICINAL AGENT, USING DEHALOGENATED COMPOUNDS FOR PREPARING ANTIBACTERIAL OR MEDICINAL AGENT | 2001 |
|
RU2298006C2 |
| TRI- OR TETPA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES | 2006 |
|
RU2420524C2 |
| GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE INGREDIENT | 2008 |
|
RU2450001C2 |
| PYRIDONE CARBOXYLIC ACID DERIVATIVES AND COMPOSITION BASED ON THEREOF | 1993 |
|
RU2100351C1 |
| ANTIBIOTIC DERIVATIVES OF 2-OXO-OXAZOLIDINE-3, 5-DIYL | 2012 |
|
RU2616609C2 |
| INDOLE AND INDAZOLE DERIVATIVES SHOWING PRESERVING ACTION ON CELLS, TISSUES AND ORGANS | 2009 |
|
RU2460525C2 |
| CONDENSED BENZAZEPINE DERIVATIVE, AN INTERMEDIATE COMPOUND FOR ITS SYNTHESIS, A PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2129123C1 |
| NEW DERIVATIVES OF PYRIDONE CARBOXYLIC ACIDS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING PATIENTS WITH INFECTIOUS DISEASES | 1993 |
|
RU2161154C2 |
