PEPTIDE AND METHOD FOR ITS PREPARATION Russian patent published in 1998 - IPC

FIELD: medicine; methods for producing biologically active substances with immunoregulatory action; may be used in medicine, veterinary practice and experimental biochemistry. SUBSTANCE: proposed is novel, synthetic, biologically active peptide with immunoregulatory action and having the formula: X-Glu-Trp-Y, where X is H or Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, aminobutyric acid, aminocapric acid; Y is Gly, Ala, Leu, Ile, Val, NVal, Pro, Tyr, Phe, Trp, D-Ala, D-Leu, D-Ile, D-Val, D-NVal, D-Pro, D-Tyr, D-Phe, D-Trp, aminobutyric acid, aminocapric acid, OH, mono- or disubstituted (C₁-C₃). amide. Peptide is synthesized in solution by progressively growing molecular chain from C-terminal and maximum blocking functional groups. Synthesis makes departure from amino acid alkyl ether and uses activated ethers, mixed anhydrides and tert.butylhydroxycarbonyl amino acids. EFFECT: higher efficiency. 2 cl, 2 tbl