FIELD: molecular biology, biochemistry. SUBSTANCE: invention relates to a method of producing high levels of functional recombinant proteins in adenovirus-transformed mammalian cells. Expression is carried out in cell line 293 of human kidney and cell line AV12 of Syrian hamster. Method involves culturing cell line 293 or AV12 transformed with recombinant expression vector containing fragment of DNA sequence encoding the end product at 38-39 C. EFFECT: increased expression levels of total protein and increased yield of functional protein. 7 cl, 2 tbl
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