COMPLEX SUBSTITUTED IMIDAZOLE COMPOUNDS HAVING ANTIDOTE AND ANTIHYPOXANTHIC ACTIVITIES Russian patent published in 1998 - IPC

Abstract RU 2115653 C1

FIELD: medicine. SUBSTANCE: present invention describes novel compounds, namely 1-vinyl- and 1-ethylimidazole complexes with zinc and cobalt salts of organic and inorganic acids of general formula: wherein R is C₂H₃, or C₂H₅; A is Zn(CH₃COO)₂,, Zn(CH₂COO)₂,, Zn(C₆H₆O₆) or CoCl₂. Said compounds have ANTIDOTE and antihypoxanthic activities. Bis (1-vinylimidazole) zinc ascorbate improves survival rate of experimental animals when carbon monoxide has acute effect of up to 67%. 1- ethyl imidazole-zinc succinate complex has high protecting activity against acute effect of nitrogen dioxide, reduces the number of experimental animals died of toxic emphysema and increases survival rate up to 75%. 1-ethyl imidazole-zinc acetate complex shows highest protection activity in case of acute hypobaric hypoxia, prolongs survival rate of experimental animals. EFFECT: synthesis of complex substituted imidazole compounds. 5 cl, 7 ex, 3 tbl

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RU 2 115 653 C1

Authors

Skushnikova A.I.

Domnina E.S.

Titunov L.A.

Chumakov V.V.

Barinov V.A.

Borodavko V.K.

Dates

1998-07-20—Published

1995-12-27—Filed