TRIAZOLOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: triazolopyrimidines of the formula (I) given in description where one of R₁ and R₂ is C_1-6-alkyl, radical (CH₂)_p-OR where p = 1-6; R - C_1-6-alkyl, hydrogen or benzyl and other - hydrogen, halide, C_1-6-alkyl, N₃,OR₄,SR₄,NR₅-R₆ or NH(CH₂)_n-NR₅R₆ where R₄ - hydrogen or (CH₂)_m-OR where m = 1-4; R¹ is C_1-6-alkyl; R₅ and R₆ are similar or different and mean hydrogen, C_1-6-alkyl, or together with nitrogen they form morpholine, pyrrolidine and piperidine group; n = 1-4; X and Y are different and mean: N and group C-R₆R₇-H,, C_1-6-alkyl, radical (CH₂)_n′-OH where n′ = 0-4, radical SR′ where R′ - as indicated above, or NR₅R₆ where R₅ and R₆ are similar or different and mean hydrogen or C_1-6-alkyl; R₃ - aminocarbonylphenyl, carboxyphenyl or radical of the formula: where Z is N or CH; X′ is S or O; R⁵ - hydrogen or when Z′ is O, halide. Synthesized compounds show antagonistic property with respect to angiotensin-II receptors and antiproliferative property that ensures to use their in pharmaceutical composition. EFFECT: improved method of synthesis, enhanced effectiveness. 11 cl, 2 tbl