ESTERS OF ACYLSULFONAMIDO- AND SULFONAMIDOPYRIDINE-2-CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND A METHOD OF ITS PREPARING Russian patent published in 1998 - IPC

FIELD: organic chemistry and technology, pharmacy. SUBSTANCE: invention relates to esters of acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid of the general formula (I) given in invention description where X means simple bond or C(O)-; R⁴ - linear or branched aliphatic -alkyl; R⁶ means radical of the formula (II) with exception for : -C-V-W where C - bond, linear or branched -alkanediyl; V means bond or hydrogen; W means -aryl. The following compounds are excluded: methyl-5-[((phenylsulfonyl)amino)carbonyl] pyridine-2-carboxylate. Compounds of the formula (I) inhibit activity of enzymes proline- and lysine hydroxylase and cause very selective inhibition of collagen biosynthesis. EFFECT: improved method of synthesis, enhanced selective inhibiting effect of collagen biosynthesis. 4 cl, 1 tbl