FIELD: organic chemistry and technology. SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R1, (II) R2 and (III) R3 and their pharmacological salts where R4 and 
- H or alkyl; R5 - halogen; 
- lower alkyl; X - group of the formulas -OCO-, 
where 
- H or lower alkyl, -CO- or other groups and Y - cycloalkyl, cycloalkylalkyl, alkynyl or other groups. Derivatives of diazepine I-III inhibit platelet activation factor and exhibit the prolonged effect of activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 11 cl, 146 ex, 1 tbl, 1 dwg
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