DERIVATIVES OF ANTHRANILIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, INTERMEDIATE COMPOUNDS USED FOR THEIR SYNTHESIS AND DRUG Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of anthranilic acid of the general formula (I) or their pharmacologically acceptable salts where R¹, R², R³ and R⁴ are similar or distinct and mean hydrogen atom, halogen atom, optionally halogenated lower alkoxy-group, nitro-, cyano-group, pyrazolyl group, group of the formula (II) where R⁹ and R¹⁰ are similar or distinct and mean hydrogen atom, lower alkyl group and p = 0-6; group of the formula (III) where R¹³ means hydrogen atom, lower alkyl group; q = 0-2; R² can be 1,2,4- -triazolyl group; R⁵ and R⁶ are similar or distinct and mean hydrogen atom, halogen atom, cyano-group, lower alkoxy-group, or R⁵ and R⁶ together with carbon atoms to which they are bound form oxolane, 1,3-dioxolane or 1,4-dioxolane ring; W means a group -N= or -CH= ; R⁷ and R⁸ are similar or distinct and mean hydrogen atom, lower alkyl group, or R¹ and R⁷ together with carbon and nitrogen atoms, respectively, to which they are bound form piperidine or pyrrolidine ring; A means hydrogen atom, optionally halogenated lower alkyl group or a group of the formula: -X-(CH₂)_m-Z where X means -CO-, -CH₂- or S(O)₂-; Z means hydrogen, halogen atom, phenyl group that can be substituted with lower alkyl, lower alkoxy-, carboxy- or lower alkoxycarbonyl-group, pyridyl group, a group of the formula NR¹¹R¹² where R¹¹ and R¹² together with nitrogen atom to which they are bound form piperidine or pyrrolidine ring and the latter can be substituted with lower alkyl group, hydroxy-, carboxy-, lower alkoxycarbonyl-, cycloalkyl-group containing 3-8 carbon atoms that can be substituted with hydroxy-, cyano-, lower alkylcarbonylhydroxy-, carboxy- or lower alkoxycarbonyl-, piperidyl-group; m = 0-6; Y - oxygen atom; n = 0-6. Invention describes also a drug eliciting inhibiting activity with respect to cyclic GMP-phosphodiesterase based on compound of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of drug. 5 cl, 143 ex