FIELD: medicine, pharmacy. SUBSTANCE: preparation has, wt.-%: drug 85, not above; addition that provides water penetration to the preparation core, 5-80; and hydrogel-forming polymer, 10-95. Polymer shows capability to gelatinize for 70%, not less, in upper part of gastroenteric tract - in gaster and small bowel. Addition providing water penetration has solubility 1 g/5 ml water, not above. Hydrogel-forming polymer has an average molecular mass 2 000 000 Da, not less, and can contain at least one polyethylene oxide. Nicardipine can be used as a drug. Preparation ensures to release a drug both in upper and lower part of gastroenteric tract - in large bowel. EFFECT: enhanced effectiveness of a preparation. 8 cl, 19 dwg, 21 ex, 21 tbl
