FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to solid pharmaceutical preparation of matrix type, which contains: (a) enterosoluble polymer based on methacrylic acid; and (b) sugar and/or sugar-alcohol, in which 1 g of sugar and/or sugar-alcohol can be dissolved in not more than 4 g of water at water temperature from 20 to 25°C. Pharmaceutical preparation does not contain softener. Pharmaceutical medicine is produced by extrusion method. Application of sugar and/or sugar-alcohol with specified properties ensures acceptable plasticity of mixture with high content of enterosoluble polymer based on methacrylic acid without addition of softener.
EFFECT: preparation by invention has satisfactory controllability of medicine release, suppressing release in upper part of gastrointestinal tract and insuring immediate release in lower part of gastrointestinal tract.
7 cl, 4 dwg, 31 tbl, 26 ex
