FIELD: organic chemistry. SUBSTANCE: (-)-enantiomer of cis-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidine-2-one is obtained subjecting for the mixture of (-)-enantiomer and (+)-enantiomer for chiral high pressure liquid chromatography or enantioselective catabolism using an enzyme. The obtained preparation is used for viral infection treatment. EFFECT: improved method of preparing. 18 cl, 4 tbl
| Title |
Year |
Author |
Number |
| (-)-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLANE-5-YL)- -(1H)-PYRIMIDINE-2-ONE, A MIXTURE OF ITS ENANTIOMERS, METHODS OF THEIR SYNTHESIS, A METHOD OF TREATMENT |
1992 |
|
RU2126405C1 |
| 1,3-OXATHIOLANE, GEOMETRICAL AND OPTICAL ISOMERS THEREOF, MIXTURES OF SAID ISOMERS, METHODS OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION HAVING ANTIVIRAL ACTIVITY |
1990 |
- Bernar Bello[Ca]
- P'Erett Bello[Ca]
- Nge Nguen-Ba[Ca]
|
RU2092485C1 |
| ANTIVIRAL COMPOSITION CONTAINING NUCLEOSIDE ANALOG, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
1992 |
- Dzhanet Mehri Kameron
- Nikolas Kammak
|
RU2139059C1 |
| METHOD OF PREPARING CIS-NUCLEOSIDE ANALOGS, THEIR SALTS AND ESTERS |
1994 |
- Tarek S.Mansur
- Kollin Ivans
- Khaolun Dzhin
- Arskhad M.Siddiku
- Allan Kh.L.Tse
|
RU2139870C1 |
| (-)-CIS-4-AMINO-1-(2-OXYMETHYL-1,3-OXATHIOLAN-5-YL-(1H)-PYRIMIDINE-2-ON IN CRYSTALLINE FORMS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION |
1992 |
- Pol Ravenskroft[Gb]
- Toni Gordon Roberts[Gb]
- Pol Ehvans[Gb]
|
RU2102393C1 |
| DIDEOXYNUCLEOSIDE ANALOGS FOR TREATING HEPATITIS B VIRUS INFECTIONS |
1993 |
- Tarek Mansaur
- Alan Kh. L. Tse
|
RU2160108C2 |
| METHOD OF DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDES, INTERMEDIATE COMPOUNDS, AND METHOD OF PREPARING INTERMEDIATE COMPOUNDS |
1992 |
- Tarek Mansur
- Khaolun Dzhin
- Allan Kh.L.Tse
- M.Arshad Siddiki
|
RU2140925C1 |
| METHODS OF PRODUCING OPTICALLY ACTIVE CIS-2-HYDROXYMETHYL-4-(CYTOSIN-1'-YL)-1,3-OXATHIOLANE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
2005 |
|
RU2430919C2 |
| METHODS FOR SEPARATING MIXTURE OF ENANTIOMERS |
1992 |
- Liotta Dennis S.
- Shinazi Rajmond F.
- Choj Vu-Baeg
|
RU2235724C2 |
| METHOD OF TREATMENT OF PATIENTS WITH INFECTIONS INDUCED BY HEPATITIS B VIRUS |
1993 |
|
RU2157215C2 |
