FIELD: medicine and veterinary practice. SUBSTANCE: described is improved method of preparing 10- methylenecarboxylate-9-acridone or 10-methylenecarboxy-9-acridone intended for synthesis of medicinal substances or medicinal forms useful in medical and veterinary practice as antiviral agent. Sodium 10-methylenecarboxylate-9- acridone or 10-methylenecarboxy-9-acridone is prepared or 10-methylenecarboxy-9- acridone is prepared by alkylation of acridone with ethylchloro acetate in the presence of sodium or potassium carbonates under conditions that enable one to prepare industrial ether of 10-methylene carboxy-9-acridone with high yield and high content of main substance and to convert it into desired products of high purity by alkaline hydrolysis and isolation of original product. EFFECT: increased yield and higher purity of the desired products. 10 cl, 9 ex, 1 tbl
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Authors
Dates
2001-02-10—Published
1998-05-19—Filed