ANTIGLUCOCORTICOID DRUG Russian patent published in 1999 - IPC

FIELD: medicine, veterinary science. SUBSTANCE: invention relates to nonsteroid antiglucocorticoid drugs of new class. Invention proposes the use of an insect pheromone of nonsteroid nature or its synthetic analog or derivative (long-chain unsaturated aliphatic alcohol, aldehyde or ester) for selective SUPPRESSION of effect of glucocorticoid hormones on mammalian cells. The length of linear hydrocarbon chain of any of proposed members is at the range from 10 to 21 carbon atoms. Also, it is possible to use two or more pheromones and/or their synthetic analogs and derivatives taken on the basis of different hydrophobicity that depends on aliphatic hydrocarbon chain length being this difference should not be less 5. Invention proposes also a pharmaceutical composition on the basis of components said. EFFECT: low toxicity, high effectiveness, improved regulation of mammalian cell sensitivity to glucocorticoid hormones effect. 4 cl, 3 tbl