FIELD: pharmaceutical industry. SUBSTANCE: invention relates to dry preparation of essentially spherical particles consisting of high-activity substance introduced into biologically compatible polymer with high boiling temperature, this polymer and above-mentioned high-activity substance being admixed under stirring to immiscible homogeneous viscous carrier. Stirring is continued until formation of biologically compatible polymer microbeads and complete introduction of high-activity substance into them are attained. Temperature of this process is not higher than vitrification temperature of polymer. EFFECT: enabled formation of microbeads with load on core material more than 15% and which have no high-activity substance on their surfaces. 16 cl, 10 ex
Authors
Dates
1999-02-10—Published
1994-05-13—Filed