NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-[(SUBSTITUTED-GLYCYL)- -AMIDO]-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to new 1,11-dioxo-2-naphthacene carboxamides of the formula (I) where X - halogen or trifluoromethanesulfonyl- -hydroxy-group; NR¹R², wherein R¹ - hydrogen - methyl; R³ - hydrogen, C_1-8-alkyl, C_6-10-aryl possibly substituted with hydroxy-group or halogen; R⁴ - H, C_1-6-alkyl; W - amino-group monosubstituted with C_1-12-alkyl with a substitute indicated in p. 1 of an invention. Compounds of the formula (I) show antibiotic activity against broad spectrum of organisms including that showing resistance to tetracyclines and they are useful as antibiotics. EFFECT: new compounds, improved method of synthesis. 11 cl, 3 dwg, 1 tbl, 76 ex