DERIVATIVES OF INDOLOCARBAZOLEIMIDE, MIXTURE OF THEIR ISOMERS AND THEIR SALTS, PHARMACEUTICAL COMPOSITION EXHIBITING ACTIVITY INHIBITING PROTEIN KINASE C OR LIGHT MYOSIN CHAIN KINASE AND INHIBITING IMMUNE RESPONSES Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to derivatives of indolocarbazoleimide of the general formula (I) where R¹ and R² - hydrogen, alkyl, cyanoalkyl, azidoalkyl and haloidalkyl, arylsulfonyloxyalkyl, aminoalkyl optionally mono- or disubstituted with alkyl at nitrogen atom and optionally substituted with hydroxyl at alkyl moiety. Two substituents at nitrogen atom in aminoalkyl-group together with nitrogen atom can form pyrrolidine ring, or mean residue of the formula (a) where n = 1-3; R¹¹ and R¹² - hydrogen, alkyl; R³-R¹⁰ - hydrogen, alkyl, alkoxy-group, halide, hydroxyl, acyloxy-group, aminoalkyl, a mixture of their isomers and their salts. Synthesized compounds are highly active inhibitors of protein kinase C or kinase of light myosin chain, or agents that inhibit immune responses. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 11 ex