METHOD OF CONVEYING BIOACTIVE AGENT TO ANIMAL FOR INITIATING IMMUNE RESPONSE Russian patent published in 1999 - IPC

Abstract RU 2127118 C1

FIELD: immunology. SUBSTANCE: invention relates to transferring a bioactive compound, usually antigen, in animal body. For that, effective quantity of bioactive compound is placed into microcapsules up to 10 mcm in size made of biologically compatible indifferent material. Effective amount of these microcapsules is introduced, mainly orally, into immunized animals. According to invention, material of microcapsules is biologically active polymer or copolymer being capable of passing through gastrointestinal tract or of localizing on a mucous surface. Microcapsules do not undergo biodegradation or undergo it to an insignificant extent. The latter ensures transfer of bioactive compound onto peyer's patches or other mucous membrane-associated lymphatic tissues. Microcapsules are incorporated therein with no loss in activity and in amounts sufficient to stimulate system immunogenesis or immune response of mucous membranes. Because of pulsing release of agent, system immunity is induced and immune system of mucous membranes activated. EFFECT: enhanced effect of bioactive compound. 16 cl, 1 dwg, 19 tbl, 12 ex

Similar patents RU2127118C1

Title Year Author Number
METHOD FOR DELIVERING BIOLOGICALLY ACTIVE COMPOUND ONTO MUCOSA-ASSOCIATED LYMPHORETICULAR ANIMAL TISSUE, METHOD FOR OBTAINING COMPOSITION AND COMPOSITION FOR DELIVERING BIOLOGICALLY ACTIVE COMPOUND 1989
  • Tajs Tomas R.
  • Dzhilli Richard M.
  • Ehldridzh Dzhon Kh.
  • Stass Dzhej K.
RU2250102C2
ENTEROTOXIN MUTANT EFFECTIVE AS NONTOXIC ORAL STIMULATION AGENT 1995
  • Dzhon D. Klements
  • Bonni L. Dikinson
RU2160606C2
MUCOSAL INFLUENZA VIRUS VACCINE AND METHOD FOR INFLUENZA PREVENTION 2004
  • Khasegava Khideki
  • Kurata Takesi
  • Sata Tetsutarou
  • Morijama Masami
  • Tamura Sin-Iti
  • Tanimoto Takefumi
RU2390351C2
ADJUVANT COMPOSITION CONTAINING POLY-GAMMA-GLUTAMIC ACID 2005
  • Sung Mun Khe
  • Kim Chjul Dzoong
  • Pu Kha Roung
  • Khong Syng Po
  • Li Dzong Su
  • Kim Dzy Uon
RU2390352C2
LIPOSOMES RENDERING THYMUS-DEPENDENT ASSISTANCE TO "WEAK" ANTIGENS USED FOR PREPARING VACCINE 1993
  • Khovard R.Siks[Us]
  • Natali Garkon[Fr]
RU2107493C1
METHOD FOR TREATING AUTOIMMUNE DISEASES USING TYPE 1 INTERFERONS 1995
  • Stejli Armstrong Brod
RU2166959C2
DNA COMPOSITION FOR INDUCING IMMUNE RESPONSE ON TUMOUR-ASSOCIATED MACROPHAGUES 2007
  • Rejsfeld Ral'F A.
  • Sjan Zhun
  • Lo Jun'Pin
RU2459631C2
ANTIBODY SELECTIVE TO APOPTOSIS INDUCING LIGAND RECEPTOR ASSOCIATED WITH TUMOR NECROSIS FACTOR, AND USES THEREOF 2001
  • Zou Tong
  • Itikava Kimikhisa
  • Kimberli Robert P.
  • Kupman Uill'Jam Dzh.
RU2298013C2
SPHINGOID POLYALKYLAMINE CONJUGATES FOR BACTERINATION 2004
  • Barenkholz Jechetskel
  • Jozef Aviva
  • Kedar Ehliezer
RU2361577C2
METHOD OF PREPARING AN ATTENUATED STRAIN OF BACTERIUM SALMONELLA AND A VACCINE 1992
  • Jan Dzhordzh Charl'Z
  • Stiven Neville Chehtfild
  • Nejl Frehzer Fejrveter
RU2126447C1

RU 2 127 118 C1

Authors

Tomas R.Tajs

Richard M.Dzhilli

Dzhon Kh.Ehldridzh

Dzhej K.Stass

Dates

1999-03-10Published

1989-03-16Filed