FIELD: medicine. SUBSTANCE: method involves applying mutant form of thermolabile enterotoxin of E. coli where arginine in position 192 is substituted with glycine that has lost its toxicity and retained its immunological activity. The enterotoxin is administered in combination with direct antigen for obtaining more pronounced immune response against the mentioned antigen when introduced as an ingredient of oral vaccine preparation. EFFECT: enhanced effectiveness of treatment. 18 cl, 5 dwg, 2 tbl
