METHOD OF PREPARING AMINO ACID N-MONOALKYL DERIVATIVES AND METHOD OF PREPARING N-ALKYL-AMINOIMINOMETHANESULFONIC ACID Russian patent published in 1999 - IPC

Abstract RU 2128166 C1

FIELD: chemical industry. SUBSTANCE: present invention describes compound of formula I: H₂N-C(=NR₁)-NH-(CH₂)_n-C←NH₂)-CO₂H or salts wherein R₁ is C_1-6 alkyl, and n is 3-5. Method comprises reacting compound of formula II: H₂N-C(=NR₁)SO₃H with compound of formula III: H₂N(CH₂)_n-C(←NH₂)CO₂H in the presence of inorganic base or oxidizing compound of formula IV: H₂N-C(=NR₁)SH with peracetic acid in polar solvent, and then in the presence of inorganic base and, subsequently reacting with compound of formula III. Method is carried out without isolation of any intermediate products. Present invention describes method of preparing compound of formula II by oxidation of compound of formula IV with peracetic acid in polar solvent. Method increases purity of final product and makes process safer. EFFECT: more efficient preparation method. 57 cl, 3 ex

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RU 2 128 166 C1

Authors

Rehjnikehnt Pehtel

Ehmrik Singkh Mehkhehl

Donal'D Llojd Vinston Berford

Dates

1999-03-27—Published

1994-05-05—Filed