N,N-DIMETHYL-2-(5-(2-OXO-1,3-OXAZOLIDINE-4-YL-METHYL)-1H-INDO- -LE-3-YL)-ETHYLAMINE, ITS PHYSIOLOGICALLY ACCEPTABLE SALT OR SOLVATE, METHOD OF ITS SYNTHESIS, DRUG USED AS AN AGONIST OF "5-HT-LIKE" RECEPTOR IN MAMMALS, METHOD OF DRUG AGENT PREPARING Russian patent published in 1998 - IPC

Abstract RU 2110517 C1

FIELD: organic chemistry. SUBSTANCE: product: N,N-dimethyl-2-[5-(2-oxo-1,3-oxazolidine-4-yl-methyl)-1H-indo- -le-3-yl] -ethylamine of the formula (I) HT•001 as its (S)- or (R)-form or their mixture or its physiologically acceptable salt or solvate. Method of synthesis involves interaction of compound of the formula (II) HT1 with compound of the formula (III) or its carbonyl-protected form where L - suitable group that can be removed or protective amino-group that under conditions in situ can be converted to dimethylamino-group, or group where and -NR1R2, - methyl. Invention proposes a drug agent containing an effective amount of compound (I) R1, method of its preparing, prophylaxis and treatment of mammals required for intake of agonist of "5-R2-like" receptor by administration of compound (I) -HT1- in mammal organism at the dose 0.01-5 mg/kg body weight as measured for free base. In part, proposed drug can be used for migraine treatment. EFFECT: improved method of synthesis, enhanced effectiveness of prophylaxis and treatment. 14 cl

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Authors

Alan Dunkan Robertson[Gb]

Alan Piter Khill[Gb]

Robert Cherl'Z Glen[Gb]

Grehm Richard Martin[Gb]

Dates

1998-05-10Published

1991-06-06Filed