METHOD OF SYNTHESIS OF ENANTIOMERIC COMPOUNDS OR THEIR DERIVATIVES Russian patent published in 1996 - IPC

Abstract RU 2068849 C1

FIELD: organic chemistry. SUBSTANCE: product: enantiometic nucleosides of the formula (I) where R - cyclopropylamine or N-cyclopropyl-N-methylamino-group; A - 2-cyclopentene-1-methanol-4-yl at configuration (1S, 4R) or (1R,4S) or their derivatives, yield is 74-95%. Reaction conditions: reagent 1: enantiomer of the formula (II) where Z - desplitting group; A - as indicated above. Reagent 2: corresponding alkylamine followed by conversion of product (I) to its salt, ester, monophosphate or esterified phosphate. Synthesized compounds were used as therapeutic agents for viral disease treatment. EFFECT: improved method of synthesis. 5 cl

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RU 2 068 849 C1

Authors

Susan Mehri Daludzh[Us]

Dates

1996-11-10Published

1990-12-21Filed