FIELD: organic chemistry. SUBSTANCE: product: enantiometic nucleosides of the formula (I) where R - cyclopropylamine or N-cyclopropyl-N-methylamino-group; A - 2-cyclopentene-1-methanol-4-yl at configuration (1S, 4R) or (1R,4S) or their derivatives, yield is 74-95%. Reaction conditions: reagent 1: enantiomer of the formula (II) where Z - desplitting group; A - as indicated above. Reagent 2: corresponding alkylamine followed by conversion of product (I) to its salt, ester, monophosphate or esterified phosphate. Synthesized compounds were used as therapeutic agents for viral disease treatment. EFFECT: improved method of synthesis. 5 cl
Title | Year | Author | Number |
---|---|---|---|
ENANTIOMERIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1992 |
|
RU2091386C1 |
SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, METHODS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIVIRAL EFFECT BASED ON THEREOF | 1993 |
|
RU2141952C1 |
4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURINE-9-YL]-2-CYCLOPENTENE- -1-METHANOL SUCCINATE AS ANTIVIRAL AGENT | 1995 |
|
RU2145324C1 |
CHLOROPYRIMIDINE INTERMEDIATE COMPOUNDS | 1995 |
|
RU2140913C1 |
METHOD OF PRODUCING GUANINE DERIVATIVES OR THEIR ACID=ADDITIVE SALTS SUITABLE FOR PHARMACY | 0 |
|
SU1634138A3 |
METHOD OF PRODUCING DERIVATIVES OF PURINE | 0 |
|
SU1342421A3 |
MONO-, DI- OR TRICOMPLEX ESTERS OF 2-AMINO-6-(C-C-ALKOXY)-9-(β-D-ARABINOFURANOSYL)-9H-PURINE, METHOD OF THEIR SYNTHESIS, USING AND PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2114860C1 |
METHOD OF SYNTHESIS OF 2'-DEOXY-2'-FLUORORIBONUCLEOSIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2043361C1 |
METHOD OF PREPARING PURINE DERIVATIVES OR THEIR SALTS | 0 |
|
SU751325A3 |
VERSIONS OF METHOD OF PRODUCING 2-AMINO-9-(2-OXYETHOXYMETHYL)-9H-PURINE | 0 |
|
SU1373323A3 |
Authors
Dates
1996-11-10—Published
1990-12-21—Filed