FIELD: molecular biology, genetic engineering, hormones. SUBSTANCE: invention relates to variants of parathyroid hormone (PTH) eliciting PTH-like activity and containing at least a single modification taken from a group involving: 
and others indicated in p. 1 of the invention claims. Fused protein is N-terminal polypeptide encoded by bacteriophage T4 gene 55 and the compound (by p. 1) bound to its C-end and if necessary linker located between these groups being a linker can be split chemically. A pharmaceutical composition containing an effective amount of the compound (by p. 1) regulates calcium metabolism. EFFECT: improved method of synthesis, regulation of metabolism. 6 cl, 9 tbl, 312 ex
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