BISPHOSPHONATE-INCLUDING COMPOSITION WITH RETARDED RELEASE Russian patent published in 2010 - IPC A61K9/08 A61K47/18 A61K47/12 A61P5/02 

FIELD: medicine.

SUBSTANCE: invention relates to pharmacology and medicine and represents pharmaceutical composition for parenteral introduction, including diaspartate or disuccinate or diglutamate salt of somatostatin analogue of formula III, where C-2 atom is in (R) or (S) configuration, or their mixture, and where R stands for NR₁₀R₁₁(C₂-C₆)alkylene or guanidine(C₂-C₆)alkylene and each of R₁₀ and R₁₁ independently represents H or C₁-C₄alkyl and water, in which pH value constitutes from 3.0 to 7.0, forming after injection gel-like system-depot in case of contact with liquid medium in organism, in which salts of somatostatin analogues are characterised by ratio salt/base within the interval from 0.1 to 2 and from said gel-like system-depot in patient's organism continuously released is salt of somatostatin analogue: diaspartate, disuccinate or diglutamate during long period of time from 1 to 90 days.

EFFECT: invention ensures obtaining compositions which include diaspartate or disuccinate or diglutamate salt of somatostatin analogue with retarded release.

17 cl, 5 ex, 4 tbl