METHOD OF PREPARING BETA-ANOMER ENRICHED NUCLEOSIDES Russian patent published in 1999 - IPC

Abstract RU 2131880 C1

FIELD: chemical industry. SUBSTANCE: method of preparing beta-anomer enriched nucleosides of formula (I): wherein T is fluorine and R is nucleoside defined in claim 1. SN2 substitution is carried out optionally in suitable solvent of sulfonyloxy groups (IV) from monomer- enriched carbohydrate of formula (II): wherein X is independently selected from hydroxy protective groups, T is as defined above, by at least monomer equivalent of corresponding nucleobase at 17 to 120 C and deblocking is carried out to form compound of formula (I). Method is stereoselective. EFFECT: more efficient preparation method. 20 cl

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RU 2 131 880 C1

Authors

Ta-Sen Chou

Lauri Mishel' Potit

Duglas Pehtton K"Ell

Kora Sju Grossman

Larri Vejn Khertel

Zichard Ehlmer Kholms

Charl'Z Dehvid Dzhouns

Tomas Ehdvard Mehbri

Dates

1999-06-20Published

1993-06-21Filed