FIELD: chemical industry. SUBSTANCE: described is method of preparing hemcitabin hydrochloride which comprises removing protecting group from β-1-(2'-deoxy-2,2'- difluoro-3', 5'-di-o-benzoyl-D-ribofuranosyl)-4- aminopyrimidin-2-one in the presence of base and alcohol and subsequently treating the resulting solution with hydrochloric acid and antisolvent and isolating the resulting solid product. EFFECT: more efficient process and increased yield of the desired product. 12 cl, 5 ex
| Title |
Year |
Author |
Number |
| METHOD OF PREPARING BETA-ANOMER ENRICHED NUCLEOSIDES |
1993 |
- Ta-Sen Chou
- Lauri Mishel' Potit
- Duglas Pehtton K"Ell
- Kora Sju Grossman
- Larri Vejn Khertel
- Zichard Ehlmer Kholms
- Charl'Z Dehvid Dzhouns
- Tomas Ehdvard Mehbri
|
RU2131880C1 |
| METHOD OF PURIFICATION AND RECOVERY OF 2'-DESOXY-2', 2'-DIFLUORONUCLEOSIDES |
1995 |
- Ta-Sen Chou
- Lori Mishel' Pote
- Duglas Patton Chell'
|
RU2161622C2 |
| METHOD OF ISOLATION OF CEFACLOR FROM A REACTION MIXTURE OF AN ENZYMATIC ACYLATION |
1994 |
|
RU2126411C1 |
| USE OF 6-HETEROCYCLO-4-AMINO-1,3,4,5-TETRAHYDROBENZ[CD]INDOLE USED IN VOMITING OR NAUSEA AT MOVING, PHARMACEUTICAL COMPOSITION |
1993 |
- Richard Nolan Bukher
- Majkl Ehdvard Flof
- Dehvid Ehrnst Lokhorn
- Charl'Z Dzhon Paget
- Dzhon Menert Shos
|
RU2138262C1 |
| NAPHTHYL DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE SUBSTANCES |
1996 |
|
RU2167849C2 |
| METHOD OF SYNTHESIS OF TETRAHYDROBENZ(C,D)INDOLE AGONISTS OF SEROTONIN |
1990 |
- Majkl Ehdvard Flau[Us]
- Mark Mortensen Foreman[Us]
|
RU2007393C1 |
| USE OF 2-PHENYL-3-AROYLBENZOTHIEPHENES, THEIR SALTS OR SOLVATES FOR INHIBITION OF OSSEOUS TISSUE LOSS, PHARMACEUTICAL COMPOSITION CONTAINING 2-PHENYL-3-AROYLBENZOTHIEPHENES AND THEIR SALTS OR SOLVATES |
1995 |
- Majkl Uil'Jam Drejper[Us]
|
RU2100024C1 |
| 4-AMINO-6-SUBSTITUTED TETRAHYDROBENZ-[C,D]-INDOLES |
1992 |
- Majkl Ehdvard Flaf[Us]
- Majkl Dzhon Martinelli[Us]
- Dzhon Menert Skauz[Us]
|
RU2073672C1 |
| METHOD OF SYNTHESIS OF 5-SUBSTITUTED PYRROLO[2,3-α]- -PYRIMIDINES |
1993 |
- Charl'Z Dzhekson Barnett
- Tomas Majkl Vilson
|
RU2127274C1 |
| DERIVATIVES OF 1-CARBA-(1-DETIA)-CEPHEME |
1993 |
- Robert Dzhon Ternanski[Us]
|
RU2107067C1 |
