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2 134 121

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C1

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IPC

(21) (22)

Application

97111267/14, 1997-07-02

(24)

Start date

1997-07-02

(22)

Actual filing date

1997-07-02

(45)

Published

1999-08-10

(72)

Inventor

Emel'Janova T.G.Nezavibat'Ko V.N.Usenko A.B.Andreeva L.A.

(73)

Holder

Institut Molekuljarnoj Genetiki Ran

HEPTAPEPTIDE ELICITING ANALGETIC ACTIVITY COMBINING WITH THERMOREGULATORY AND/OR VASOMOTOR ACTIVITY AND/OR WITH EFFECT ON BEHAVIOR RESPONSE OF TESTING ORGANISM AND METHOD OF ALTERNATION OF PHYSIOLOGICAL ACTIVITY OF DERMORPHINE Russian patent published in 1999 - IPC

Abstract RU 2134121 C1

FIELD: medicine, pharmacology, chemistry of peptides. SUBSTANCE: invention relates to new synthesized physiologically active heptapeptides of the general formula: H-Tyr-D-Ala-Phe-Gly-Tyr-X-Ser-NH2 where X is D-Pro or Dh-Pro or Dh-D-Pro where Dh-Pro is 3,4-dehydroproline. Method proposes a chemical modification at 6-th amino acid residue Pro to alternate a physiological activity of the known natural heptapeptide dermorphine of the general formula: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Novel compounds show analgetic activity in combination with thermoregulatory and/or vasomotor activity and/or effect on behavior activity of testing organism. EFFECT: improved method of alternation, new properties of heptapeptide. 3 cl, 14 tbl, 6 dwg, 8 ex

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RU 2 134 121 C1

Authors

Emel'Janova T.G.

Nezavibat'Ko V.N.

Usenko A.B.

Andreeva L.A.

Dates

1999-08-10—Published

1997-07-02—Filed

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