SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES, INTERMEDIATE COMPOUNDS AND PHARMCOMPOSITION Russian patent published in 1999 - IPC

Abstract RU 2135473 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to substituted 1,2,3,4-tetrahydroisoquinolines of the formula (I) where R₁,R₂ - hydrogen atom, nitro-, carboxy-group, lower alkyl, alkoxy-, amino-group; n - a whole number 0-2; R₃ is alkoxy-group; R₄ is CO₂R₆; R₆ - hydrogen atom or lower alkyl; R₅ is COR₇; R₇ - aralkyl, diaralkyl or NR₈R₉ where R₈,R₉ - hydrogen atom, alkyl, aryl; X is O or absent, or their pharmaceutically acceptable salts and a pharmaceutical composition on their base that are effective for treatment of patients with chronic progressive sickness of cognitive capability. EFFECT: enhanced effectiveness of compounds. 16 cl, 48 ex

Similar patents RU2135473C1

Title	Year	Author	Number
METHOD OF OBTAINING SUBSTITUTED ACUL DERIVATIVE OF 1,2,3,4-TETRAHYDROISOQUINOLINE--3-CARBOXYLIC ACID OR PHARMACEUTICALLY ACCEPTED SALTS	0	Milton Luis Khoufl Silvestr Kluchko	SU1148560A3
METHOD OF PRODUCING NAPHTHYRYDINE QUINOLINE- OR BENZOXAZINE CARBOLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OF ACID ADDITION	0	Taunli P.Kulbertson Dzhon M.Domagala Tomas F.Mich Dzheffri B.Nikols	SU1360584A3
METHOD FOR PRODUCING QUINOLINECARBOXYLIC ACID DERIVATIVES OR ACID-ADDITIVE SALTS THEREOF	0	Taunli P.Kubertson Dzhon M.Domagala Tomas F.Mich Dzheffr B.Nikols	SU1314954A3
METHOD OF PRODUCING SUBSTITUTED OCTAHYDRO-1-(W-MERCAPTOALKANOYL)-1H-INDOLE-2-CARBOXYLIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF	0	Milton Luis Khoufl Dzhordzh Bobovski	SU1246893A3
METHOD OF SYNTHESIS OF (S)-(-)- AND (R)-(+)-ISOMERS OF (5-AMINO-1,2-DIHYDRO-2-METHYL-3-PHENYLPYRIDO-[3,4-B]-PYRAZINE- -7-YL)-CARBAMIDE ACID ETHYL ESTER OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND INTERMEDIATE (S)-(-)- AND (R)-(+)-ISOMERS OF [6-AMINO-4-[[2-(ALKOXYALKYLAMINO)-1-METHYL-2-OXOETHYL]-AMI- -NO]-5-NITRO-2-PYRIDINYL]-CARBAMIDE ACID ETHYL ESTER	1994	Om Prakash Goehl[Us] Sham Shridkhar Nikam[In]	RU2098409C1
METHOD FOR PRODUCING SUBSTITUTED 6-ARYL-3(2A)-PYRIDAZINONES	0	Ila Sirkar Dzhejms Artur Bristol	SU1313346A3
DERIVATIVES OF BENZOTHIAZINE DIOXIDE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING INHIBITORY ACTIVITY OF ENDOTHELIN RECEPTOR AND METHOD OF INHIBITION OF ENDOTHELIN RECEPTOR	1996	Kent Ehlen Berrimehn Ehmi Mehj Bunker Annete Mehriehn Doehrti Dzheremi Dzhon Ehdmunds	RU2164225C2
METHOD OF PREPARING DERIVATIVES OF 1-OHYAPORPHYN	0	Iogannes Khartenshtajn Gerkhard Zattsinger	SU878194A3
ARYLTHIOCOMPOUNDS, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION	1995	Dzhon Majkl Domadzhela Ehdvard Fejtz Ehlslejdzher Rokko Din Dzholiotti	RU2156236C2
METHOD OF PRODUCING DERIVATIVES OF QUINOLINECARBOXYLIC ACID	0	Taunli P.Kubertson Dzhon M.Domagala Toma F.Mich Dzheffri B.Nikols	SU1321376A3

RU 2 135 473 C1

Authors

Klifton Dzhon Blehnklej

Dzhon Kuk Khodges

Sil'Vester Klachko

Dates

1999-08-27—Published

1993-04-19—Filed