HOMODIMER P40 OF INTERLEUKIN-12 Russian patent published in 1999 - IPC

Abstract RU 2135584 C1

FIELD: biotechnology. SUBSTANCE: invention relates to a protein containing two subunits of interleukin-12 p40 that are associated by at least one disulfide bond preferably and exhibiting molecular mass about 80 kDa. Homopolymer p40 (molecular mass is 80 kDa) acts as an antagonist or interleukin-12 receptors. Subunit p40 has an aminoacid sequence SEQIDNO:I given in description. Homopolymer p40 is able to bind with interleukin-12 receptors but not mediating the cellular proliferation. EFFECT: homodimer indicated above. 4 cl, 18 dwg, 1 tbl

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RU 2 135 584 C1

Authors

Moris Kent Gejtli

Dzhon Khakimi

Ping Ling

Dates

1999-08-27—Published

1994-06-28—Filed