FIELD: molecular biology, genetic engineering. SUBSTANCE: invention relates to inhibition of gene activity, namely recombinant DNA used as an agent for inhibition of RNA function in living organism. Recombinant DNA has the nucleotide sequence encoding tRNA and transcribed by polymerase-III. Between signals of initiation and termination in the indicated nucleotide sequence the nucleotide sequence encoding ribosime is located. Obtained recombinant DNA ensures to inhibit RNA function in living organism effectively. EFFECT: high effectiveness of recombinant DNA. 17 dwg, 1 tbl, 8 ex
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