COMPOUNDS OF 3-SUBSTITUTED 1-ARYLINDOLE AND PHARMACEUTICAL COMPOSITION BASED ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to 3-substituted 1-arylindole of the formula (I) where Ar - phenyl possibly substituted with halogen atom; X is OCH₂,CH₂ or CH₂CH₂; dotted line means the optional bond; R¹-R⁴ - hydrogen, halogen atom, lower alkyl, lower alkoxy-, hydroxy-, nitro-, lower alkylthio-, lower alkylsulfonyl-, lower alkyl- or dialkylamino-, cyano-, trifluoromethyl-, trifluoro- -methylsulfonylhydroxy- and trifluoromethylthio-group; R⁵ - hydrogen atom, hydroxy-, lower alkoxy-group, halogen atom, trifluoromethyl-, lower alkyl group optionally substituted with hydroxy-group, or lower alkenyl optionally substituted with hydroxyl; R⁶,R⁸ - hydrogen atom; R⁸ - lower alkyl, lower alkenyl (other values are given in p. 1 of the invention claim). These compounds show the basic antiserotoninergic activity and some of their - an additional antidopamine-ergic activity. Compounds of the formula (I) can be used for treatment of patients with anxiety, aggression, depression, sleep disorder, migraine, schizophrenia by binding 5HT₂--receptors and D₂--receptors. EFFECT: valuable pharmacological properties of compounds. 12 cl, 1 tbl, 16 ex