HETEROCYCLIC COMPOUNDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to compound of the formula (I) where Xⁱ is N or C-R⁶; X² is N or CR⁷; X³ is N or R⁸; R¹,R⁴,R⁵ - hydrogen or halogen atom; R² - halogen atom; R³ - H, nitro-, amino-group possibly substituted with lower alkyl, acyl, phenyl(lower)-alkyl, carboxyalkyl, alkoxycarbonylalkyl or pyridyl; piperazinyl possibly substituted with halogen atom, lower alkyl, acyl, phenyl, oxo-, nitro-, amino-group, phenyl(lower)-alkyl or lower alkoxycarbonylalkyl; R⁶,R⁸ - H, halogen atom, alkyl, OH, NH₂, alkylthio-group; R⁷ - H or alkyl; A - lower alkylene; Q is O or N-R⁹ where R⁹ - hydrogen atom or acyl, or its pharmaceutically acceptable salts showing activity as bradykinine antagonists and can be used for prophylaxis and treatment of sickness where bradykinine acts as a linking agent. EFFECT: improved method of synthesis and treatment. 12 cl, 73 ex