COMPOUND OF 4-PHENYLPIPERAZINE, 4-PHENYLPIPERIDINE AND 4-PHENYL- -1,2,3,6-TETRAHYDROPYRIDINE AND PHARMACEUTICAL COMPOSITION ELICITING 5-HT- AND D-ACTIVITY Russian patent published in 1999 - IPC

Abstract RU 2140920 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the compound of 4-phenylpiperazine, 4-phenylpiperidine and 4-phenyl-1,2,3,6- -tetrahydropyridine of the formula (I) where A is C3-8-alkylene; R1 is C3-10-alkyl, cycloalkyl, cycloalkyl-lower alkyl, trifluoromethylsulfonyl or alkylsulfonyl; W is O; V is NR2; R2 is H, lower alkyl, adamantyl or phenyl possibly substituted with halogen atom; Z is (CH2)m where m = 2 or Z means -CH=CH-; dotted line indicates an optional bond and if this bond is absent then X is N or CH; if this bond presents then X means C, and its pharmaceutically acceptable acid-additive salt showing effect on the central serotonin 5-HT1A- and dopamine D2-receptors. New compounds are benefit in treatment of patients with some mental and neurological disorders. EFFECT: enhanced curative effectiveness of compounds. 6 cl, 2 tbl, 10 ex

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RU 2 140 920 C1

Authors

Ens Kristian Perregor

Ehjner Knud Mol'Tzen

Dates

1999-11-10Published

1995-06-08Filed