DERIVATIVES OF PIPECOLINIC ACID AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pipecolinic acid of the general formula (I) where X - groups R₃OCO,R₄CO,R₅OCH₂CO; R₈ is CHNHA-CO; R₃ - lower alkyl or benzyl; R₄ - phenyl substituted with lower alkyl or halide; R₅ - phenyl possibly mono- or disubstituted with lower alkyl; R₈ - H, lower alkyl, carbamylmethyl, (N-methyl)-carbamyl or hydroxymethyl; A - the group R₉-CO; R₉ - lower alkyloxy-, benzyloxy-, naphthalenyl- or quinolinyl-group or R₆NR₇CO; R₆ is pyridinylmethyl; R₂,R₇ - lower alkyl; R₁ - H, halide; Y - cyclohexyl, phenyl, benzyl, W(CH₂)_nZ; W - oxo-, thio- or sulfonyl-group; Z - phenyl possibly monosubstituted with halogen atom, pyridinyl- or pyrimidinyl-group; n = 0 or 1 and their salts that show an antiviral activity, mainly inhibiting protease activity. EFFECT: valuable biochemical properties of compounds. 5 cl, 7 tbl, 12 ex