FIELD: organic chemistry. SUBSTANCE: product: amino acid derivatives of the formula (I) $$$ where: R - benzylhydroxycarbonyl or 2-quinolylcarbonyl. Reagent 1: 2-[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N-tert.-butyl-decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide. Reagent 2: N-(benzylhydroxycarbonyl)-alpha-asparagine. Reaction conditions: in the presence of hydroxybenzotriazole, N-ethylmorphine and dicyclohexylcarbodiimide in dry tetrahydrofuran. Synthesized compounds were used as inhibitors of viral protease. EFFECT: improved method of synthesis.
| Title |
Year |
Author |
Number |
| AMINO ACID DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE BASIC SALTS THEREOF METHODS OF PREPARING AMINO ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION HAVING ANTIVIRAL ACTIVITY |
1992 |
- Dzhosef Armstrong Martin[Gb]
- Garez Dzhon Tomas[Gb]
|
RU2109731C1 |
| CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL AGENT |
1994 |
- Peter Angern
- Chung-Chen Vej
|
RU2130939C1 |
| SUBSTITUTED PYRROLS |
1994 |
- Vil'Jam Kharris
- Kristofer Khju Khill
- Dzheffri Loton
|
RU2141960C1 |
| 2-(2-AMINO-1,6-DIHYDRO-6-OXOPURIN-9-YL)METOXY-3-HYDROXY- 1-PROPANYL-L-VALINATE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD OF PREPARING THEREOF, PHARMACEUTICAL COMPOSITION AND HYDROXY AND/OR AMINO PROTECTED 2-(2- AMINO-1,6-DIHYDRO-6-OXOPYRIN-9-YL) METHOXY-3-HYDROXY-1- PROPANYL-L-VALINATE |
1995 |
- Dzhon Dzh.Nestor
- Skott V.Vombl
- Khans Maag
|
RU2133749C1 |
| ACETIC ACID DERIVATIVES |
1994 |
- Alig Leo
- Khadvari Pol'
- Khjurtseler Mjuller Marianne
- Mjuller Marsel'
- Shtajner Beat
- Veller Tomas
|
RU2151768C1 |
| ISOQUINOLINE CARBOXAMIDES AND MEDICINAL AGENT BASED ON THEREOF FOR USING AS INHIBITORS OF HIV PROTEASE |
2001 |
- Martin Dzhozef Armstrong
- Redsho Salli
- Suollou Stiven
- Tomas Garet Dzhon
|
RU2265016C2 |
| BETA-LACTAMS |
1995 |
- Kristian Khjubshverlen
- Filipp Pfliger
- Zhan-Ljuk Speklin
- Markus Beringer
|
RU2143435C1 |
| DERIVATIVES OF 3-β-ALKENYLPENAM AND THEIR PHARMACEUTICALLY COMPATIBLE SALTS |
1994 |
- Kristian Khubshverien
- Khans Rikhter
- Zhan-Ljuk Speklin
|
RU2139290C1 |
| 8-AMINO-[1,2,4]TRIAZOLO-[1,5-A]PYRIDINE-6-CARBOXYLIC ACID AMIDE AND MEDICINAL AGENT COMPRISING THEREOF |
2002 |
- Nettekoven Mattias Genrikh
- Shmitt Sebast'En
|
RU2296763C2 |
| SULFONEAMIDOCARBOXAMIDES, THEIR HYDRATES AND PHYSIOLOGICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION ON SAID |
1993 |
- Zhan Akermann
- David Banner
- Klaus Gubernator
- Kurt Khil'Pert
- Zherar Shmid
|
RU2133739C1 |
