FIELD: bioorganic chemistry, biochemistry, pharmacy.
SUBSTANCE: invention relates to novel aspartyl derivatives of histamine of the general formula (I): 
, wherein R means hydrogen atom (H), 
or 
, or 
that are able to modulate activity of enzymes of antioxidant protection - superoxide dismutase (SOD) and catalase. Also, invention relates to using the known compounds of the general formula (I) for the same designation wherein at the same values of X the value R represents acetyl group, and to their pharmaceutically acceptable salts. Also, invention relates to a pharmaceutical composition possessing capacity to modulate activity of SOD and catalase and comprising the effective amount of compound of the general formula (I), and to a method for synthesis of compounds of the general formula (I). Method involves interaction of pentafluorophenyl ester Nα-Z-, β- or α-benzyl ester of aspartic acid with histamine followed by hydrogenolysis without isolation of intermediated protected derivatives of aspartyl histamine.
EFFECT: improved method of synthesis, valuable biochemical properties of derivatives.
12 cl, 3 tbl, 2 sch, 2 dwg, 8 ex
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