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2 141 837

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C1

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Application

97108032/14, 1997-05-19

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Start date

1997-05-19

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Actual filing date

1997-05-19

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Published

1999-11-27

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Inventor

Savina A.A.Tolkachev O.N.Glyzin V.I.Bykov V.A.Stikhin V.A.Shejchenko V.I.Kopylova I.E.Lasskaja O.F.Gromakova A.I.

(73)

Holder

Nauchno-Proizvodstvennoe Ob"Edinenie Nauchno-Issledovatel'Skij Institut Lekarstvennykh I Aromaticheskikh Rastenij"

METHOD OF PREPARING SANGUIRITRIN Russian patent published in 1999 - IPC

Abstract RU 2141837 C1

FIELD: pharmaceutical industry. SUBSTANCE: crumbled overground part of Macleaya microcarpa or Macleaya cordata is extracted with hydrophobic solvent in presence of alkali agent to precipitate bisulfates of desired alkaloids. Alkaloid salts are purified by treating filtered and alkalized aqueous solution with organic solvent, and organic phase is then treated with aqueous sulfuric acid solution. As extractant in solid-phase extraction step, ethylacetate or dichloroethane are used and extraction is carried out by successively treating several portions of raw material with one volume of extractant in countercurrent mode. As above-mentioned alkali agent in extraction step, aqueous solution of ammonia or potassium bicarbonate are used, extractant being ethylacetate or toluene. Extraction purification is carried out at 50-60 C with rate preventing formation of alkaloid precipitate. Extract thus obtained is washed with water and treated with sulfuric acid solution. Precipitate is filtered off and washed with acetone. EFFECT: simplified process and reduced cost price of product. 4 tbl, 4 ex

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RU 2 141 837 C1

Authors

Savina A.A.

Tolkachev O.N.

Glyzin V.I.

Bykov V.A.

Stikhin V.A.

Shejchenko V.I.

Kopylova I.E.

Lasskaja O.F.

Gromakova A.I.

Dates

1999-11-27—Published

1997-05-19—Filed

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