METHOD OF SYNTHESIS OF 3-HYDROXY-5-[2-(DIMETHYLAMINO)-ETHYL]- -2,3-DIHYDRO-4-(METHOXYPHENYL)-1,5-BENZOTHIAZEPINE-4-(5H)-ON'E METHOD OF SYNTHESIS OF BENZOTHIAZEPINE DERIVATIVES, METHOD OF SYNTHESIS OF CIS-(+)-3-ACETOXY-5-[2-(DIMETHYLAMINO)-ETHYL]- -2,3-DIHYDRO-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPINE-4-(5H)-ON'E Russian patent published in 1999 - IPC

Abstract RU 2141957 C1

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method of synthesis of 3-hydroxy-5- -[2-(dimethylamino)-ethyl]-2,3-dihydro-4-(methoxyphenyl)-1,5- -benzothiazepine-4-(5H)-on'e of the general formula (I) and its salts that can be used for synthesis of pharmaceutically active compounds, for example, diltiazem that is used in cardiovascular therapy. Method involves the reaction of N-alkylation of 3-hydroxy-2,3-dihydro-4-(methoxyphenyl)-1,5- -benzothiazepine-4-(5H)-on'e of the formula (II) with (dimethylamino)-ethyl halide and this reaction of N-alkylation is carried out in the reaction mixture containing 2-butanol and water. EFFECT: simplified method, increased effectiveness and safety as compared with the known ones, high purity of the end product. 11 cl, 2 ex

Similar patents RU2141957C1

Title	Year	Author	Number
METHOD OF PREPARING DILTHIAZEM	1996	Martti Khjutenen	RU2139853C1
METHOD OF PRODUCING DERIVATIVES OF 1,5-BENZTHIAZEPINE OR THEIR SALTS	0	Khirozumi Inou Khisao Otsuka	SU1544187A3
METHOD OF SYNTHESIS OF 1,5-BENZOTHIAZEPINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS	0	Khirozumi Inoue Tsunekhiro Kharada Masaaki Nagasava	SU1838305A3
METHOD FOR THE SYNTHESIS OF 1,5-BENSOTHIAZEPINE DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS	0	Khirozumi Inoue Tsunekhiro Kharada Masaaki Nagasava	SU1709908A3
METHOD OF OBTAINING DERIVATIVES OF 8-CHLORINE-1,5-BENZOTHIAZEPINE OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS OF ACIDS	0	Mikio Takeda Tokuro Okh-Isi Khiromiti Nakadzima Taku Nagao	SU1362401A3
	0	Khirozumi Inoue Tsunekhiro Kharada Masaaki Nagasava	SU1784041A3
METHOD FOR PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS	0	Mikio Takeda Tokuro Okh-Isi Khiromiti Nakadzima Taku Nagao	SU1632372A3
DERIVATIVES OF BENZAZEPINE AND BENZOTHIAZEPINE	1989	Dehvid M.Flojd[Us] Dzhon T.Khant[Us] Spenser D.Kimboll[Us] Dzhon Krehpcho[Us] Dzhagabandkhu Das[Us] Dzhordzh S.Rovnjak[Us] Dzhoel S.Barrish[Us]	RU2090562C1
METHOD OF PRODUCING DERIVATIVES OF 1,5-BENZTHIAZEPINE	0	Susumu Nagao Katsukhiko Kurabayasi Nobuyuki Futamura Khidefumi Kinosita Tosio Takakhasi	SU1194276A3
PROCESS FOR PREPARATION OF N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPINE-4-YL)-6-METHYL-QUINAZOLINE-4-AMINE	2015	Chen Tszyunli Zhen I She Tszin Van Lin Yuj Tszyankhua Chzhan Gotsaj	RU2664643C2

RU 2 141 957 C1

Authors

Martti Khjutenen

Dates

1999-11-27—Published

1995-09-15—Filed