FIELD: organic chemistry. SUBSTANCE: product: derivatives of benzazepine and benzothiazepine of the formula (I): , or their pharmaceutically acceptable salts where: R1 - lower alkoxy, OH, lower alkanoyloxy, OCONY8Y9; X - CH2 or S. If X - CH2 then R2 means and others; if X - S then R2 means and others; R3 - lower alkoxy and others; R4 - lower alkoxy and others. Reagent 1: compound of the formula (I) where: R2 means H. Reagent 2: base. Reaction conditions: in inert solvent followed by treatment with compound of the formula R2-L where L - splitting off group. Synthesized compounds can be used in medicine since they show vasodilator activity. EFFECT: improved method of synthesis. 37 cl
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Authors
Dates
1997-09-20—Published
1989-05-23—Filed