FIELD: biotechnology, antibiotics. SUBSTANCE: the strain Streptomyces cremeus subsp. nebramycini FBM-0002 as a producer of monocomponent apramycin is obtained from the population of the strain St. cremeus subsp. nebramycini N 2242 forming nebramycin complex (apromycin and tobramycin) by induced mutagenesis and the following selection of clones showing the resistance to analogs of amino acids. The new strain shows the enhanced synthesis of apramycin at biological activity 5000 mcg/ml. EFFECT: increased synthesis and activity of the strain. 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRAIN STREPTOMYCES CHROMOPURPUREUS SUBSPECIES CHIKETAMANUS FBM-0001 - A PRODUCER OF OMOMYCIN | 1996 |
|
RU2086651C1 |
| STRAIN OF STREPTOMYCES CREMEUS 1979 - A PRODUCER OF APRAMYCIN | 1996 |
|
RU2110577C1 |
| STRAIN OF STREPTOALLOTEICHUS CREMEUS SUBSP TOBRAMYCINI VKPM S-1084- PRODUCER OF APRAMICYNE AND METHOD OF APRAMICYNE OBTAINING | 2007 |
|
RU2392311C2 |
| STRAIN STREPTOMYCES AVERMITILIS PBM 0004 PRODUCING OLIGOMYCINS | 1999 |
|
RU2160780C1 |
| METHOD FOR PREPARATION OF INOCULUM MATERIAL - A PRODUCER OF AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF STREPTOMYCES CREMEUS SUBSP "NEBRAMYCINI" | 0 |
|
SU1735366A1 |
| STRAIN Streptoalloteichus cremeus subsp tobramycini ALL-RUSSIAN COLLECTION OF INDUSTRIAL MICROORGANISMS Ac-1083 - PRODUCENT OF TOBRAMYCIN AND METHOD OF OBTAINING IT | 2010 |
|
RU2433169C1 |
| ENZYMATIC NUTRIENT MEDIUM FOR PREPARATION OF AMINOGLYCOSIDE ANTIBIOTIC COMPLEX | 0 |
|
SU1735368A1 |
| INOCULUM NUTRIENT MEDIUM FOR PREPARATION OF AMINOGLYCOSIDE ANTIBIOTIC COMPLEX | 0 |
|
SU1735367A1 |
| METHOD FOR PREPARATION OF AMINOGLYCOSIDE ANTIBIOTIC COMPLEX | 0 |
|
SU1735369A1 |
| STRAIN STREPTOMYCES AVERMITILIS - A PRODUCER OF AVERMECTINES | 1992 |
|
RU2048520C1 |
