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IPC

C12N1/20(2006-01-01)

C12P1/06(2006-01-01)

C12R1/01(2006-01-01)

(21) (22)

Application

2007110925/13, 2007-03-26

(24)

Start date

2007-03-26

(22)

Actual filing date

2007-03-26

(45)

Published

2010-06-20

(72)

Inventor

Lapchinskaja Ol'Da Anastas'EvnaLavrova-Balashova Majja FedorovnaPonomarenko Valerij IvanovichKatrukha Genrikh StepanovichPreobrazhenskaja Marija Nikolaevna

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Po Izyskaniju Novykh Antibiotikov Im. G.F.Gauze Ramn

STRAIN OF STREPTOALLOTEICHUS CREMEUS SUBSP TOBRAMYCINI VKPM S-1084- PRODUCER OF APRAMICYNE AND METHOD OF APRAMICYNE OBTAINING Russian patent published in 2010 - IPC C12N1/20 C12P1/06 C12R1/01 

Abstract RU 2392311 C2

FIELD: medicine.

SUBSTANCE: method involves cultivation of strain Streptoalloteichus cremeus subsp. tobramycini VKPM S-1084, producer of apramicyne. Emanation of apramicyne from culture fluid with sorption on carboxylic cationites followed by chromatographic purification with two-column method by stepwise elution with solutions (0.19-0.22)n of ammonia. The resulting eluate is concentrated in vacuum and precipitated with excess of acetone apramicyne in the form of sulfate.

EFFECT: increased output of apramicyne.

2 cl, 1 tbl, 2 ex

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RU 2 392 311 C2

Authors

Lapchinskaja Ol'Da Anastas'Evna

Lavrova-Balashova Majja Fedorovna

Ponomarenko Valerij Ivanovich

Katrukha Genrikh Stepanovich

Preobrazhenskaja Marija Nikolaevna

Dates

2010-06-20—Published

2007-03-26—Filed

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